Cellular reprogramming by the conjoint action of ERa, FOXA1, and GATA3 to a ligand-inducible growth state
نویسندگان
چکیده
1 Cancer Biology and Pharmacology 2, Genome Institute of Singapore, Singapore, 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3 Computational and Mathematical Biology, Genome Institute of Singapore, Singapore and 4 Department of Computer Science, School of Computing, National University of Singapore, Singapore 5 These authors contributed equally to this work * Corresponding author. Genome Institute of Singapore, 60 Biopolis, Singapore 138672, Singapore. Tel.: þ 65 6808 8038; Fax: þ 65 6808 9051; E-mail: [email protected]
منابع مشابه
Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state
Despite the role of the estrogen receptor α (ERα) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERα into ERα-negative cells paradoxically has been growth inhibition. We mapped the binding profiles of ERα and its interacting transcription factors (TFs), FOXA1 and GATA3 in MCF-7 breast carcinoma cells, and observed that these three TFs fo...
متن کاملA novel FOXA1/ESR1 interacting pathway: A study of Oncomine™ breast cancer microarrays
Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is not fully understood. FOXA1 and GATA binding protein 3 (GATA3) along with ESR...
متن کاملI-5: Fifteen Years after Dolly: The Perspectives on Cellular Reprogramming
s:1202:"It is a truly amazing time to developmental biology. During recent decades, three important breakthroughs have been developed: (i) isolation of stem cells from embryo, (ii) animal cloning by nuclear transfer (NT), and (iii) and induced pluripotent stem cells (iPS). Considering these three approaches of "Cellular Reprogramming", it seems that the required elements for cell therapy now ex...
متن کاملI-10: Transcriptomics in Oocyte Mediated Cellular Reprogramming
a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...
متن کاملFOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis.
FOXA1, estrogen receptor alpha (ERalpha) and GATA3 independently predict favorable outcome in breast cancer patients, and their expression correlates with a differentiated, luminal tumor subtype. As transcription factors, each functions in the morphogenesis of various organs, with ERalpha and GATA3 being established regulators of mammary gland development. Interdependency between these three fa...
متن کامل